MIRD Monograph: Radiobiology and Dosimetry for Radiopharmaceutical Therapy with Alpha-Particle Emitters
Editor: George Sgouros, PhD

The potential of alpha-particle emitters to treat cancer has been recognized since the early 1900s. The success and recent FDA approval of an alpha-emitter–based radiopharmaceutical for prostate cancer patients has led to renewed interest in the use of alpha-particle emitters in humans for targeted therapy. Because of the nature of alpha-particle radiation, this new treatment modality is fundamentally different from existing therapies. This monograph reviews pioneering and current studies related to targeted alpha-particle-emitter therapy and provides guidance and recommendations for human dosimetry.

75 pages; 2015